| 08/18/2022 | vs Delaware St. | W | 3-0 | 1-0-0, 0-0-0 | 0-0-0 | 427 | Sara D'Appolonia (2) (Izzy Lane) Raychel Speicher (1) (Izzy Lane , Sara D'Appolonia) Sara D'Appolonia (2) (Raychel Speicher , Izzy Lane)
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| 08/21/2022 | at Villanova | T | 1-1 | 1-0-1, 0-0-0 | 0-0-0 | 565 | Lea Panagiotidis (1) (Lauren Elwell , Grace Harvey)
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| 08/25/2022 | at Virginia Tech | L | 0-2 | 1-1-1, 0-0-0 | 0-0-0 | 603 | |
| 08/28/2022 | at Richmond | L | 0-1 | 1-2-1, 0-0-0 | 0-0-0 | 520 | |
| 09/01/2022 | vs Lehigh | T | 2-2 | 1-2-2, 0-0-0 | 0-0-0 | 297 | Raychel Speicher (2) (Izzy Lane) Sara D'Appolonia (3) (Emily McNesby)
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| 09/04/2022 | at Seton Hall | T | 0-0 | 1-2-3, 0-0-0 | 0-0-0 | 489 | |
| 09/08/2022 | at Saint Francis (PA) | L | 0-1 | 1-3-3, 0-0-0 | 0-0-0 | 123 | |
| 09/11/2022 | vs Sacred Heart | L | 1-3 | 1-4-3, 0-0-0 | 0-0-0 | 157 | Sara D'Appolonia (4) (Raychel Speicher)
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| 9/18/2022 | at Princeton | L | 0-1 | 1-5-3, 0-0-0 | 0-0-0 | 765 | |
| 09/22/2022 | at UNCW | L | 0-1 | 1-6-3, 0-1-0 | 0-1-0 | 421 | |
| 09/25/2022 | at Col. of Charleston | L | 1-2 | 1-7-3, 0-2-0 | 0-2-0 | 307 | Sara D'Appolonia (5) (Raychel Speicher , Maddie Schepers)
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| 09/29/2022 | vs Elon | W | 3-0 | 2-7-3, 1-2-0 | 1-2-0 | 287 | Katie Hackley (2) Sara D'Appolonia (5) Katie Hackley (2) (Raychel Speicher)
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| 10/02/2022 | vs Towson | T | 1-1 | 2-7-4, 1-2-1 | 1-2-1 | 174 | Raychel Speicher (3) (Katie Hackley)
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| 10/06/2022 | vs Stony Brook | L | 0-1 | 2-8-4, 1-3-1 | 1-3-1 | 167 | |
| 10/09/2022 | vs Hofstra | T | 0-0 | 2-8-5, 1-3-2 | 1-3-2 | 257 | |
| 10/13/2022 | at Monmouth | L | 1-3 | 2-9-5, 1-4-2 | 1-4-2 | 101 | Lea Panagiotidis (2) (Izzy Lane , Lauren Elwell)
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| 10/16/2022 | at Northeastern | L | 0-3 | 2-10-5, 1-5-2 | 1-5-2 | 211 | |
| 10/23/2022 | vs Drexel | L | 1-2 | 2-11-5, 1-6-2 | 1-6-2 | 372 | Zoe Smith (1) (Izzy Lane)
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